Amyotrophic Lateral Sclerosis Essay Example for Free

Amyotrophic Lateral Sclerosis Essay Imagine being not able to move your muscles freely everyday, and that process has to coordinate between the brain and the spinal cord to tell the muscles to move. However, when this coordination is challenged and can not convey signals, the results are no muscle movement. At first, muscles in the hands, arms, and legs feel weak. The hands and feet twitch. Speaking and eventually breathing become difficult, and paralysis occurs in the final stages, although thinking and other cognitive functions remain intact. Death usually occurs within five years of the onset of symptoms. This rare, progressive disorder is also known as Lou Gehrig’s disease, after a famous baseball player whose life was cut short by it. What is Amyotrophic Lateral Sclerosis? Nowadays, more and more persons are being detected with a condition that is signified as â€Å"Amyotrophic Lateral Sclerosis†. In the history, this neurological situation was signified by several as â€Å"Lou Gehrig’s disorder† (Hohnsbeen, 2008). Those that suffer from this medical condition endure great complexities. This is essentially because of the fact that the disorder quickly wages war against some nerve cells in the body. These cells are recognized as neurons by medical experts. The neurons that are alluring to the disorder are the ones that are absolutely liable for the control of muscles that are deemed to be voluntary. The muscles in the upper body as well as those in the lower body are influenced. The influenced neurons are situated in the brain as well as the spinal cord and finally die (Hohnsbeen, 2008). In this direction, one will learn the facts adjacent the neurological state of amyotrophic lateral sclerosis. When a person is detected with amyotrophic lateral sclerosis, the advancement of the disorder may be gradual or it may be rapid. It all depends on the general health of the individual, how long they have had the condition previous to diagnosis, plus any other medical circumstances that they may endure from (Phillies, 1995). Seeing that the reason of this severe neurological condition is unidentified, medical experts often have a hard time deciding the speed in which the condition improvements. Nevertheless, it is a fact that it will improve and signs observed will become more demanding to the functionality of the body. Difficulties that engage the muscles of the body that are utilized for different purposes will be experienced (Phillies, 1995). It is not common for the amyotrophic lateral sclerosis sufferer to experience difficulties such as problems in walking, situations in which it is challenging to eat and swallow as suitable, and several may even face severe medical emergencies such as the failure to breathe properly. The cause of amyotrophic lateral sclerosis is not identified, though a significant step toward deciding the cause came in 1993 when scientists found that changes in the gene that generates the Cu/Zn superoxide dismutase (SOD1) enzyme were related with some cases (about twenty-percent) of familial Amyotrophic lateral sclerosis. This enzyme is an influential antioxidant that defends the body from harm caused by superoxide, a toxic free radical produced in the mitochondria (William, 2000). Free radicals are very reactive molecules made by cells during normal metabolism again mostly by the mitochondria. Free radicals can build up and cause harm to both mitochondrial and nuclear DNA and proteins within cells. Proof proposes that inability of defenses against oxidative pressure up-regulates programmed cell death (apoptosis), among several other potential results. Although it is not yet obvious how the SOD1 gene mutation leads to motor neuron degeneration, examiners have theorized that an accumulation of free radicals may consequence from the faulty functioning of this gene. New study, nevertheless, points out that motor neuron death is not probably a consequence of lost or compromised dismutase activity, proposing mutant SOD1 induces toxicity in some other way (William, 2000). Researches engaging transgenic mice have yielded many hypotheses about the role of SOD1 in mutant SOD1 familial amyotrophic lateral sclerosis. Mice lacking the SOD1 gene totally do not usually develop amyotrophic lateral sclerosis, although they do demonstrate an acceleration of age-associated muscle atrophy (sarcopenia) and a shortened lifespan (Wade, 2001). This points out that the toxic properties of the mutant SOD1 are a consequence of a gain in function rather than a loss of normal function. Additionally, aggregation of proteins has been found to be a common pathological aspect of both familial and sporadic amyotrophic lateral sclerosis. Fascinatingly, in mutant SOD1 mice, totals of mutant SOD1 were discovered only in disordered tissues, and large amounts were detected during motor neuron degeneration. It is observed that whole deposit of mutant SOD1 carries out a role in disturbing cellular functions by harmful mitochondria, proteasomes, protein folding chaperones, or other proteins (Phillies, 1995). Any such trouble, if shown, would lend large credibility to the hypothesis that aggregates are engaged in mutant SOD1 toxicity. Opponents have noted that in humans, SOD1 mutations cause only two-percent or so of general cases and the etiological mechanisms may be different from those liable for the sporadic type of the disorder. To date, the amyotrophic lateral sclerosis SOD1 mice remain the best model of the disorder for preclinical researches but it is expected that more helpful models will be developed (Wade, 2001). There are several signs that are indicated to the situation of amyotrophic lateral sclerosis. In most sufferers, the first sign related with the situation was a weakness in the body. This weakness is generally related with a particular muscle. It may happen in the face. Several have endured from a common weakness in the tongue. It could also happen in other parts of the body, such as the hands or the legs. This is a symptom that the neurons that are liable for motor functions are facing death (Mitsumoto, 2009). In several cases, the weakness will expand to other parts of the body. As the neurons experience death as a consequence of amyotrophic lateral sclerosis, they are not capable to relay the suitable signals to the brain. As a consequence, the muscles simply do not realize that they are supposed to move in one way or another. Over time, they are employed less and less. Weakness sets in to the muscles, and then they lose their mass. As the neurological situation improvements, other signs will start to happen. Muscle twitching is an ordinary sign. The twitching may be in the type of sore cramps for several, but this is not always the situation. An individual that has amyotrophic lateral sclerosis may start to notice that simple tasks engaging the hands may become more challenging. Several may discover that their talking and the capability to use their mouth for eating and swallowing are more complicated. Finally, walking will become problem. Those that are detected with amyotrophic lateral sclerosis will often find that they feel weak and comparatively tired, but they are capable to carry on doing tasks that engage cognitive capability such as concentrating on projects such as reading, memorization and often capable to focus with little to no difficulties at all (Mitsumoto, 2009). Conclusion Amyotrophic lateral sclerosis is a situation that is deemed to be deadly. Unluckily, there is no treatment for this situation. Once the disorder has started to impact the body, the harm that it produces will extend (Hohnsbeen, 2008). The collapse to the condition is that most of the sufferers that endure it will be influenced with a failure of the respiratory system. The average time span in which this happens is within 3 to 5 years from the onset of the disease. This generally results in death. Nevertheless, there have been several people that have surpassed a lifespan of ten years once diagnosed. If you have currently been examined, keep in mind to work carefully with your physician when it comes to cures. Finding a support group can also show to be extremely helpful when it comes to coping with the progress of the neurological situation.

Differing Opinions of Bleak House Essay -- Bleak House essay

Differing Opinions of Bleak House When Bleak House, by Charles Dickens, was published in 1853, it did not go unnoticed by critics. The reviews of the period where anything but tepid in tone or opinion in regard to Dickens’ newest novel. Most notably, the critics were concerned with the structure of the novel, characterization, and, in particular, Esther as a plausible character. By singling out reviewers from different publications of the time, it is possible to see what the public in 1853 was reading about Bleak House in regard to these issues. Structure The contemporary reviewers of Bleak House fall into two categories when discussing its structure. There are those who like it and there are those who do not. More specifically, those who dislike the novel’s construction complain of the absence of plot and lack of connection between characters and their actions. Opposing this view are the reviewers who find the characters in Bleak House remarkably intertwined in the story, especially since it was written as a series for a literary magazine. One of the strongest of these critics is George Brimley, who, in his article entitled â€Å"Dickens’s Bleak House† published in The Spectator in 1853, writes that â€Å"Bleak House is, even more than its predecessors, chargeable with not simple faults, but absolute want of construction†(161). He finds that the structure of Bleak House fails because there is no connection between actors and incidents. Brimley points to the interest of Richard Carstone in the Chancery case. The case only serves to draw out Carstone’s personality faults that would have been drawn out in any other interest he may have had. The Chancery case, then, is trivial for it fails to exert any real impact on the characters... ...made more probably by the fact that she is the chronicler of her own perfection†(161). Chesterton concludes, â€Å"Miss Summerson in some ways is a failure† (166). Individuals encountering life-changing moments would be swayed and impacted greatly, unlike Esther, whose enduring calmness and optimism restrains her to the fictional role. The character of Esther is widely criticized for her perfection as a character, both receiving positive acclaims and negative feedback. Esther’s reserved, quiet character illustrates the role of women during the Victorian period and what little impact on society women played. Critics of Bleak House generally praise the narration and Dickens’s use of Esther’s character, which gives direction to the novel.    Works Cited Harris, Laurie Lanzen, ed. Nineteenth-Century Literature Criticism. Vol. 8. Detroit: Gale Research Company, 1981.

Ipl Scandals

————————————————- The  Indian Premier League  (IPL) is a professional league for  Twenty20  cricket  championship in  India. It was initiated by the  Board of Control for Cricket in India  (BCCI), headquartered in  Mumbai,Maharashtra[3][4]  and is supervised by  BCCI  Vice President  Rajeev Shukla,[5]  who serves as the league's Chairman and  Commissioner. It is currently contested by nine teams, consisting of players from around the cricketing world. ————————————————-However, the league has been engulfed byseries of corruption scandals. ————————————————- Controversies involving the Indian Premier League From Wikipedia, the free encyclopedia The  Board of Control for Cricket in India  (BCCI) has found itself in the middle of many conflicts with various cricket boards around the world as a result of the  Indian Premier League  (IPL). The main point of contention was that signed players should always be available to their country for international tours, even if it overlaps with the IPL season.To address this, the BCCI officially requested that the  International Cricket Council  (ICC) to institute a time period in the International Future Tours Program, solely for the IPL season. This request was not granted at a subsequent meeting held by the ICC. [1] Contents  Ã‚  [hide]   * 1  Conflicts with the England and Wales Cricket Board * 2  Media restrictions * 3  Conflict with Cricket Club of India * 4  Suspension of Lalit Modi * 5  Chirayu Amin named IPL interim chairman * 6  Termination of the Kochi franchise * 7  2012 spot fixing case * 8  References| ——â€⠀Ã¢â‚¬â€Ã¢â‚¬â€Ã¢â‚¬â€Ã¢â‚¬â€Ã¢â‚¬â€Ã¢â‚¬â€Ã¢â‚¬â€Ã¢â‚¬â€Ã¢â‚¬â€Ã¢â‚¬â€Ã¢â‚¬â€Ã¢â‚¬â€Ã¢â‚¬â€- edit]Conflicts with the England and Wales Cricket Board Because the inaugural IPL season coincided with the  County Championship  season as well as  New Zealand's  tour of  England, the  ECB  and county cricket clubs raised their concerns to the BCCI over players. The ECB made it abundantly clear that they would not sign No Objection Certificates for players—a prerequisite for playing in the IPL. Chairmen of the county clubs also made it clear that players contracted to them were required to ulfill their commitment to their county. As a result of this,  Dimitri Mascarenhas  was the only English player to have signed with the IPL for the 2008 season. [2] A result of the ECB's concerns about players joining the IPL, was a proposed radical response of creating their own Twenty20 tournament that would be similar in structure to the IPL. The league — titled the  Twenty20 English Premier League  Ã¢â‚¬â€ would feature 21 teams in three groups of seven and would occur towards the end of the summer season. 3]  The ECB enlisted the aid of  Texas  billionaire  Allen Stanford  to launch the proposed league. [4]  Stanford was the brains behind the successful  Stanford 20/20, a tournament that has run twice in the  West Indies. On 17 February 2009, when news of the fraud investigation against Stanford became public, the ECB and  WICB  withdrew from talks with Stanford on sponsorship. [5][6]  On February 20 the ECB announced it has severed its ties with Stanford and cancelled all contracts with him. [7] ————————————————- [edit]Media restrictionsInitially the IPL enforced strict guidelines to media covering matches, consistent with their desire to use the same model sports leagues in North America use in regards to media coverage. Notable guidelines imposed included the restriction to use images taken during the event unless purchased from  cricket. com, owned by Live Current Media Inc (who won the rights to such images) and the prohibition of live coverage from the cricket grounds. Media agencies also had to agree to upload all images taken at IPL matches to the official website. This was deemed unacceptable by print media around the world.Upon the threat of boycott, the IPL eased up on several of the restrictions. [8]  On 15 April 2008 a revised set of guidelines offering major concessions to the print media and agencies was issued by the IPL and accepted by the  Indian Newspaper Society. [9] ————————————————- [edit]Conflict with Cricket Club of India As per IPL rules, the winner of the previous competition decides the venue for the finals. [10]  In 2009, the reigning Champions,  Deccan Chargerschose the  Brabourne Stadium  in  Mumbai. [10]  However, a dispute regarding use of the avilion meant that no IPL matches could be held there. The members of the  Cricket Club of India  that owns the stadium have the sole right to the pavilion on match days, whereas the IPL required the pavilion for its sponsors. [11]  The members were offered free seats in the stands, however the club rejected the offer, stating that members could not be moved out of the pavilion. [10][12][13] ————————————————- [edit]Suspension of Lalit Modi On 25 April 2010, the BCCI suspended  Lalit Modi, the IPL chairman, for â€Å"alleged acts of individual misdemeanours†.The suspension notice was served on him by Rajeev Shukla, BCCI vice-president, and N Srinivasan, the board secretary, sending an e-mail to the same effect. It followed a da y of negotiations with interlocutors attempting to persuade Modi to resign but pre-empted a potentially flashpoint at a scheduled IPL governing council meeting, which Modi had said he would attend. Modi was officially barred from participating in the affairs of the Board, the IPL and any other committee of the BCCI. [14] ————————————————- edit]Chirayu Amin named IPL interim chairman Chirayu Amin, an industrialist and head of the  Baroda Cricket Association, was named interim chairman of the IPL by the BCCI, following Lalit Modi's suspension. [15]  According to BCCI, many important documents were missing from the IPL and BCCI offices. â€Å"Many of the records are missing. The IT is asking for documents. We don't have them. We have asked BCCI CAO Prof Ratnakar Shetty to look into the missing records and papers,† said BCCI President Shashank Manohar. [16] — ———————————————- edit]Termination of the Kochi franchise On September 19, 2011, the newly elected BCCI president N Srinivasan, after the annual general meeting in Mumbai, announced that the Kochi Tuskers Kerala IPL franchise was terminated by the BCCI for breaching its terms of agreement. Under the terms of the agreement, each franchise has to submit a bank guarantee every year that covers the fee payable to the BCCI. The 2010-founded team was bought for Rs 1,550 crore and the consortium has to pay a bank guarantee of  156 crore every year till 2020. 17]  The consortium that owns Kochi is reported to have defaulted on an annual payment of  156 crores as a bank guarantee. In April 2010, the BCCI's working committee had rejected demands from Kochi and Pune Warriors for a reduction in their franchisee fees. The two new franchises, which made their debuts in 2011, had sought a 25% waiver on the grounds that the BCCI had stated in the bidding document that each team would play 18 league matches in a season. The schedule was later reduced to 14 matches per team. ————————————————- edit]2012 spot fixing case Main article:  2012 Indian Premier League spot fixing case On 14 May 2012, an Indian news channel  India TV  aired a  sting operation  which accused 5 players involved in  spot fixing. Reacting to the news, Indian Premier League president  Rajiv Shukla  immediately suspended the 5 uncapped players. The five players were,  TP Sudhindra  (Deccan Chargers),  Mohnish Mishra  (Pune Warriors), Amit Yadav,  Shalabh Srivastava  (Kings XI Punjab) and  Abhinav Bali, Delhi cricketer . [18]  However, the report went on to claim that none of the famous cricketers were found guilty.On the reliability of the report,  Rajat Sha rma, the  editor-in-chief  of news channel  India TV  quoted that the channel had no doubts about the authenticity of the sting operation and prepared to go to court. [19] Mohnish Mishra who was part of  Pune Warriors India  team for the season, admitted to have said that franchises pay black money, in a sting operation. Mishra was caught on tape saying that franchisees paid them black money and that he had received  1. 5  crore  (US$273,000)  from the later, among which  1. 2  crore  (US$218,400)  was black money. [20]  He was also suspended from his team. [21]

1918 Spanish Flu Pandemic Pictures